Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2015
EDTF Date Created
2015
Description
G-quadruplexes (G4s) are nucleic acid structures formed from π-stacked planar sets of four Hoogsteen hydrogen bonded guanine bases. G4s emerged as potential therapeutic targets based on their ability to modulate gene expression and inhibit the ability of telomerase to elongate chromosomal telomeres. Raman spectroscopy, polarized Raman spectroscopy, surface-enhanced Raman spectroscopy (SERS), and other optical spectroscopic techniques were used to characterize the G4s formed by four different DNA sequences: human telomeric (HT), thrombin-binding aptamer (TBA), nuclease hypersensitive element III1 region of the c- Myc gene promoter (Myc), and a single loop-isomer of Myc (MycL1).
Language
Type
Form
Extent
367 p.
Subject (Topical)
Identifier
FA00004370
Additional Information
Includes bibliography.
Dissertation (Ph.D.)--Florida Atlantic University, 2015.
FAU Electronic Theses and Dissertations Collection
Date Backup
2015
Date Created Backup
2015
Date Text
2015
Date Created (EDTF)
2015
Date Issued (EDTF)
2015
Extension
FAU
IID
FA00004370
Organizations
Attributed name: Florida Atlantic University
Attributed name: Charles E. Schmidt College of Science
Attributed name: Department of Chemistry and Biochemistry
Person Preferred Name
Friedman, Samantha
author
Graduate College
Physical Description
application/pdf
367 p.
Title Plain
Raman and surface-enhanced raman spectroscopy of G-quadruplexes
Use and Reproduction
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2015
2015
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Raman and surface-enhanced raman spectroscopy of G-quadruplexes
Other Title Info
Raman and surface-enhanced raman spectroscopy of G-quadruplexes