Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2019
EDTF Date Created
2019
Description
The lens is responsible for focusing light into the retina. It accomplishes this through its maturation from an epithelial cell into a fiber cell. A large amount of research has been done on cellular differentiation. Nevertheless, we still lack knowledge on many different aspects of differentiation, including a complete theory on the mechanism behind differentiation. Due to the lens’ unique structure and cell types, this is an ideal model for studying differentiation. Our research has shown that αB crystallin, a small heat shock protein, is able to modulate cytochrome C levels and protect the mitochondria under oxidative stress. Also, cytochrome C release is often followed by caspase 3 activation. In addition, research has shown that low levels of caspase 3 activation is essential in driving differentiation. My work examined if αB crystallin could modulate cytochrome C to lower caspase 3 levels to allow for differentiation rather than apoptosis.
Language
Type
Form
Extent
36 p.
Subject (Topical)
Identifier
FA00013293
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2019.
FAU Electronic Theses and Dissertations Collection
Date Backup
2019
Date Created Backup
2019
Date Text
2019
Date Created (EDTF)
2019
Date Issued (EDTF)
2019
Extension
FAU
IID
FA00013293
Organizations
Attributed name: Florida Atlantic University
Attributed name: Charles E. Schmidt College of Medicine
Attributed name: Department of Biomedical Science
Person Preferred Name
Cherubin, Patrice
author
Graduate College
Physical Description
application/pdf
36 p.
Title Plain
REGULATION OF CASPASE-3 ACTIVATION BY PHOSPHORYALTED Ab-CRYSTALLIN AND ITS ROLE IN DIFFERENTIATION
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2019
2019
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
REGULATION OF CASPASE-3 ACTIVATION BY PHOSPHORYALTED Ab-CRYSTALLIN AND ITS ROLE IN DIFFERENTIATION
Other Title Info
REGULATION OF CASPASE-3 ACTIVATION BY PHOSPHORYALTED Ab-CRYSTALLIN AND ITS ROLE IN DIFFERENTIATION