THE RELATIONSHIP OF GENE EXPRESSION, STRESS, DEPRESSION, AND THE SOCIAL DETERMINANTS OF HEALTH DURING PREGNANCY

The purpose of this study was to explore differences in perceived stress, glucocorticoid receptor (GR), and the expression of histone acetylation (HAT) of the corticotropin-releasing hormone (CRH) gene between non-Hispanic Black and non-Hispanic White women in their 2nd trimester of pregnancy. Black women are 2–3 times more likely to experience preterm birth (PTB) and maternal mortality than White women (Hoyert, 2022; Martin et al., 2019). Researchers have reported chronic stress associated with factors such as experiencing discrimination, financial hardship, and abuse may induce dysregulation of the stress hormones (Kramer et al., 2013; Shapiro-Mendoza et al., 2016). Likewise, the stress hormones glucocorticoid and CRH dysregulation have been linked to early labor, preeclampsia, and maternal death (Kramer et al., 2013; Shapiro-Mendoza et al., 2016; Yu et al., 2013). Additionally, social status, gender, education, and income are recognized as social determinants of health.
This study used an observational, cross-sectional design to analyze the differences in perceived stress, depression, GR, and HAT of the CRH gene between a group of Black and White pregnant women in their 2nd trimester of pregnancy. This study analyzed perceived stress, depression, and peripheral blood monocytes cells (PMBC) using secondary, deidentified data from pregnant women. The Perceived Stress Scale was used to measure stress, the profile in Mood Depression Scale measured depression, a chromatin immunoprecipitation (ChIP) to quantitative Polymerase chain reaction (qPCR) analysis was used to measure GR and HAT of the CRH gene. The data were analyzed using correlation and analysis of covariance (ANCOVA) to examine relationships and the differences between groups.