Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2014
EDTF Date Created
2014
Description
Obesity is associated with elevated levels of the pro-inflammatory cytokines
interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), contributing to systemic
insulin resistance. Fibroblast growth factor 21 (FGF21) is a vital metabolic and
inflammatory regulator, however circulating FGF21 concentrations are elevated in obese
individuals. Acute aerobic exercise increases systemic FGF21 in normal-weight
individuals, however the effect of acute aerobic exercise on plasma FGF21 response and
the relationships with inflammation (IL-6 and TNF-α), insulin resistance, and energy
expenditure in obese individuals is unknown. Following 30 minutes of treadmill running
at 75% VO2max, plasma FGF21 response, as indicated by area-under-the-curve “with
respect to increase” (AUCi) analyses, was attenuated in 12 obese compared to 12 normalweight
subjects. Additionally, FGF21 AUCi positively correlated with glucose AUCi,
total relative energy expenditure, and relative VO2max, suggesting that cardiorespiratory fitness levels may predict FGF21 response, contributing to the enhanced regulation of
glucose and energy metabolism.
interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), contributing to systemic
insulin resistance. Fibroblast growth factor 21 (FGF21) is a vital metabolic and
inflammatory regulator, however circulating FGF21 concentrations are elevated in obese
individuals. Acute aerobic exercise increases systemic FGF21 in normal-weight
individuals, however the effect of acute aerobic exercise on plasma FGF21 response and
the relationships with inflammation (IL-6 and TNF-α), insulin resistance, and energy
expenditure in obese individuals is unknown. Following 30 minutes of treadmill running
at 75% VO2max, plasma FGF21 response, as indicated by area-under-the-curve “with
respect to increase” (AUCi) analyses, was attenuated in 12 obese compared to 12 normalweight
subjects. Additionally, FGF21 AUCi positively correlated with glucose AUCi,
total relative energy expenditure, and relative VO2max, suggesting that cardiorespiratory fitness levels may predict FGF21 response, contributing to the enhanced regulation of
glucose and energy metabolism.
Language
Type
Form
Extent
54 p.
Subject (Topical)
Identifier
FA00004229
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2014.
FAU Electronic Theses and Dissertations Collection
Date Backup
2014
Date Created Backup
2014
Date Text
2014
Date Created (EDTF)
2014
Date Issued (EDTF)
2014
Extension
FAU
IID
FA00004229
Organizations
Attributed name: Florida Atlantic University
Attributed name: College of Education
Attributed name: Department of Exercise Science and Health Promotion
Person Preferred Name
Slusher, Aaron L.
author
Graduate College
Physical Description
application/pdf
54 p.
Title Plain
Relationships of fibroblast growth factor 21 with inflammation and insulin resistance in response to acute exercise in obese individuals
Use and Reproduction
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2014
2014
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Relationships of fibroblast growth factor 21 with inflammation and insulin resistance in response to acute exercise in obese individuals
Other Title Info
Relationships of fibroblast growth factor 21 with inflammation and insulin resistance in response to acute exercise in obese individuals