Tolerance to amphetamine-induced hypophagia is lost when drug injections are withdrawn for 4 weeks while milk tests are continued (Wolgin and Hughes 1996). The purpose of this study was to determine whether the loss of tolerance is a function of drug withdrawal per se. Rats made tolerant to amphetamine (2 mg/kg, IP) were assigned to one of three groups. During the next 4 weeks (phase), one group continued to receive amphetamine injections prior to daily milk tests (Before group), one group received drug injections after the milk tests (After group), and one group received injections of saline prior to the milk tests (Saline group). Dose-response tests revealed that the Before group retained tolerance, whereas the After and Saline groups lost tolerance.
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Publisher
Springer-Verlag
Date Issued
1997-08-01
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Subject (Topical)
Identifier
228486
Additional Information
Tolerance to amphetamine-induced hypophagia is lost when drug injections are withdrawn for 4 weeks while milk tests are continued (Wolgin and Hughes 1996). The purpose of this study was to determine whether the loss of tolerance is a function of drug withdrawal per se. Rats made tolerant to amphetamine (2 mg/kg, IP) were assigned to one of three groups. During the next 4 weeks (phase), one group continued to receive amphetamine injections prior to daily milk tests (Before group), one group received drug injections after the milk tests (After group), and one group received injections of saline prior to the milk tests (Saline group). Dose-response tests revealed that the Before group retained tolerance, whereas the After and Saline groups lost tolerance.
This manuscript is a version of an article published in Psychopharmacology (1997) 132:342–349. The original publication is available at www.springerlink.com
Department of Psychology Charles E. Schmidt College of Science
Date Backup
1997-08-01
Date Text
1997-08-01
DOI
10.1007/s002130050354
Date Issued (EDTF)
1997-08-01
Extension
FAU
FAU
admin_unit="FAU01", ingest_id="", creator="super:SPATEL", creation_date="2009-09-16 11:38:48", modified_by="super:FAUDIG", modification_date="2013-09-11 12:36:55"
IID
FADT228486
Issuance
single unit
Person Preferred Name
Wolgin, David L.
creator
wolgindl@fau.edu
Title Plain
Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia
Origin Information
Springer-Verlag
1997-08-01
single unit
Title
Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia
Other Title Info
Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia