Secobatzelline A (1), a new batzelline natural analogue, and secobatzelline B (2), a likely artifact formed during the isolation procedure, have been isolated from a deep-water marine sponge of the genus Batzella. Secobatzellines A and B inhibited the phosphatase activity of calcineurin, and secobatzelline A inhibited the peptidase activity of CPP32. Both compounds showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of secobatzellines A (1) and B (2) are described.
This document is the accepted manuscript version of a published work that appeared in final form in Environmental Science & Technology after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np990177a. This article may be cited as: Gunasekera, S. P., McCarthy, P. J., Longley, R. E., Pomponi, S. A., & Wright, A. E. (1999). Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella. Journal of Natural Products, 62(8), 1208–1211.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1297.