Structure-activity relationship studies of Discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity

Discodermolide, a natural product from the marine sponge Discodermia dissoluta, has been previously described as an antimitotic agent with microtubule hyperstabilizing properties similar to those of paclitaxel (Taxol). The clinical success of paclitaxel has led to a growing interest in novel antimitotic compounds and the elucidation of their structure-activity characteristics.

This manuscript is a version of an article with the final publication found online at http://www.springerlink.com and may be cited as: Isbrucker, Richard A., Sarath P. Gunasekera and Ross E. Longley (2001) Structure‐activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity, Cancer Chemotherapy and Pharmacology 48:29-36 doi:10.1007/s002800100287

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1396.

Date Backup

2001

Date Text

2001

DOI

10.1007/s002800100287

Date Issued (EDTF)

2001

Extension

FAU
FAU
admin_unit="FAU01", ingest_id="ing7737", creator="creator:SPATEL", creation_date="2010-10-07 13:37:56", modified_by="super:FAUDIG", modification_date="2014-02-10 12:06:19"

IID

FADT2783239

Issuance

single unit

Organizations

Attributed name: Harbor Branch Oceanographic Institute

Person Preferred Name

Isbrucker, Richard A.

creator

Physical Description

pdf
9 p.

PURL

http://purl.flvc.org/FCLA/DT/2783239