Note
Thesis (M.S.)--Florida Atlantic University, 1999.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
1999
Description
The formation of polymeric derivatives of the cancer drug Cis-dichlorodiaminoplatinum (II), cis-DDP, by the reaction of (1-4)-2-acetamide-2-deoxy-beta-D-glucose (Chitosan) with potassium tetrachloroplatinate is reported. Chelation of (1-4)-2-acetamide-2-deoxy-beta-D-glucose by tetrachloroplatinum (II) occurred through the amine groups leaving the hydroxyls unreacted and free to assist in making the products water soluble. It was hoped that such compounds would retain the anti tumor activity of cis-DDP but produce fewer toxic side effects. Structural characterization involved infrared spectroscopy, mass spectroscopy, EDAX analytical methods. Products were also analyzed using light scattering photometry, elemental analysis and solubility studies. Additionally, the biological activity of water-soluble products was tested against selected cell lines.
Language
Type
Form
Extent
73 p.
Subject (Topical)
Identifier
9780599419155
ISBN
9780599419155
Additional Information
Thesis (M.S.)--Florida Atlantic University, 1999.
Date Backup
1999
Date Text
1999
Date Issued (EDTF)
1999
Extension
FAU
FAU
admin_unit="FAU01", ingest_id="ing1508", creator="staff:fcllz", creation_date="2007-07-19 04:50:35", modified_by="staff:fcllz", modification_date="2011-01-06 13:09:24"
IID
FADT15699
Issuance
monographic
Organizations
Attributed name: Florida Atlantic University
Person Preferred Name
Francis, Ann-Marie
Graduate College
Physical Description
73 p.
application/pdf
Title Plain
synthesis of chitosan-cis-DDP derivative
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
1999
monographic
Boca Raton, Fla.
Florida Atlantic University
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
synthesis of chitosan-cis-DDP derivative
Other Title Info
The
synthesis of chitosan-cis-DDP derivative