Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2020
EDTF Date Created
2020
Description
Matrix Metalloproteinase-13 (MMP-13) belongs to a large family of proteolytic enzymes which are characterized by their ability to degrade the extracellular matrix components. MMP-13 appears to have a critical role in tumor invasion and metastasis. In this study, several fluorogenic probes specific for MMP-13 were designed and characterized. These synthesized probes could be modified with chelators to be applied for imaging MMP-13 in breast cancer and/or multiple myeloma models. The activity and selectivity of MMP-13 and other MMPs against these probes were studied through two approaches. It was found that these probes were cleaved by all MMPs, but MMP-13 showed the highest activity and selectivity towards these peptides.
Language
Type
Form
Extent
73 p.
Subject (Topical)
Identifier
FA00013507
Rights
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2020.
FAU Electronic Theses and Dissertations Collection
Date Backup
2020
Date Created Backup
2020
Date Text
2020
Date Created (EDTF)
2020
Date Issued (EDTF)
2020
Extension
FAU
IID
FA00013507
Organizations
Attributed name: Florida Atlantic University
Attributed name: Department of Chemistry and Biochemistry
Attributed name: Charles E. Schmidt College of Science
Person Preferred Name
Ibrahim, Mariam
author
Graduate College
Physical Description
online resource
73 p.
Title Plain
Synthesis of Fluorogenic Probes Specific for Matrix Metalloproteinase 13
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2020
2020
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Synthesis of Fluorogenic Probes Specific for Matrix Metalloproteinase 13
Other Title Info
Synthesis of Fluorogenic Probes Specific for Matrix Metalloproteinase 13