Marine organisms, particularly sponges, have been a prolific source of unique steroids and also of halogenated metabolites-isoprenoid, acetate, or shikimate-derived. Yet, amazingly, not a single halogenated marine steroid has so far been reported. We now describe the first three halo steroids, which we isolated from the sponge Strongylacidon sp., whose major cytotoxic constituents are kiheisterones A and B (1, 2).
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00064a041. This article may be cited as: Carney, J. R., Scheuer, P. J., & Kelly-Borges, M. (1993). Three unprecedented chloro steroids from the Maui sponge Strongylacidon sp.: kiheisterones C, D, and E. Journal of Organic Chemistry, 58(12), 3460-3462. doi:10.1021/jo00064a041
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #955.