Tolerance to amphetamine hypophagia: a real-time depiction of learning to suppress stereotyped movements in the rat

To analyze how tolerance develops to amphetamine-induced hypophagia, the authors recorded real-time licking responses in rats given chronic injections of the drug and access to milk for 30 min. Initially, licking was greatly reduced and occurred only late in the session. The acquisition of tolerance was characterized by a decrease in the latency to initiate licking, a gradual increase in the number of licks, and a reorganization of the temporal licking pattern such that licks were distributed throughout the session, interspersed with pauses. On posttolerance dose-response tests, licking was directly proportional to drug dose in some rats. The results support the view that tolerance to amphetamine hypophagia involves a behavioral adaptation to the motor effects of the drug.