Total synthesis and biological evaluation of novel C2–C6 region analogues of dictyostatin

By exploiting a Still–Gennari HWE coupling with a common C11–C26 aldehyde, a series of C2–C6 modified analogues of the microtubule-stabilising marine natural product dictyostatin were synthesised and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including the (P-glycoprotein efflux-mediated) Taxol-resistant NCI/ADR cell line.

This manuscript is a version of an article published by Elsevier www.elsevier.com/locate/bmc and may be cited as Paterson, Ian, Nicola M. Gardner, Esther Guzman, Amy E. Wright. (2009). Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin. Bioorganic & Medicinal Chemistry, 17(6) 2282-2289 doi:10.1016/j.bmc.2008.10.084 and is available at www.sciencedirect.com

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1735.

Date Backup

2009-03-15

Date Text

2009-03-15

DOI

10.1016/j.bmc.2008.10.084

Date Issued (EDTF)

2009-03-15

Extension

FAU
FAU
admin_unit="FAU01", ingest_id="ing5487", creator="creator:SPATEL", creation_date="2010-03-30 14:54:26", modified_by="super:FAUDIG", modification_date="2014-02-10 08:23:23"

IID

FADT1745595

Issuance

single unit

Person Preferred Name

Paterson, Ian

creator

Physical Description

pdf
9 p.

PURL

http://purl.flvc.org/FCLA/DT/1745595

Title Plain

Total synthesis and biological evaluation of novel C2–C6 region analogues of dictyostatin

URL

http://purl.flvc.org/FCLA/DT/1745595

Origin Information

Elsevier B.V.
2009-03-15
single unit

Title

Total synthesis and biological evaluation of novel C2–C6 region analogues of dictyostatin

Other Title Info

Total synthesis and biological evaluation of novel C2–C6 region analogues of dictyostatin