Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin

Dictyostatin-1 had previously been isolated from a marine sponge of the genus Spongia sp. and described as a cytotoxic agent to murine and human cancer cells, but its mechanism of activity was unknown. In a routine screening assay used to detect cytotoxic compounds of marine origin, dictyostatin-1 was identified as a highly active component in an extract from a Lithistida sponge and exploration into its pharmacology was pursued.

This is the author’s version of a work accepted forpublication by Elsevier. Changes resulting from the publishing process, including peer review,editing, corrections, structural formatting and other quality control mechanisms, may not bereflected in this document. Changes may have been made to this work since it was submittedfor publication. The definitive version has been published athttp://www.elsevier.com/locate/biochempharm and may be cited as Isbrucker, Richard A.,Jennifer Cummins, Shirley A. Pomponi, Ross E. Longley, Amy E. Wright (2003) Tubulinpolymerizing activity of dictyostatin‐1, a polyketide of marine sponge origin, Biochemical Pharmacology 66(1):75–82 doi:10.1016/S0006-2952(03)00192-8

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1509.