Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea

Member of
HBOI Faculty Contributions
Contributors
Reddy, N. Srinivasa
Reed, John K.
Longley, Ross E.
Wright, Amy E.
Publisher
American Chemical Society and American Society of Pharmacognosy
Date Issued
2005
Note

The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC50’s of 18.8, 2.7, and 15.6 µg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC50 of 18.7 µg/mL.

Language
English
Type
Text
Genre
article
Extent
4 p.
Subject (Topical)
Paramuricea placomus
Deep-sea ecology
Cnidaria
Azulene
Spectrum analysis
Identifier
3164111
Additional Information
The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC50’s of 18.8, 2.7, and 15.6 µg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC50 of 18.7 µg/mL.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. Toaccess the final edited and published work see http://dx.doi.org/10.1021/np040147u. Thisarticle may be cited as: Reddy, N. S., Reed, J. K., Longley, R. E., & Wright, A. E. (2005). TwoNew Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea. Journal of Natural Products, 68(2), 248-250.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1571.
Date Backup
2005
Date Text
2005
DOI
10.1021/np040147u
Date Issued (EDTF)
2005
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing9357", creator="creator:BCHANG", creation_date="2011-04-25 13:58:01", modified_by="super:FAUDIG", modification_date="2014-02-10 14:27:14"

IID
FADT3164111
Issuance
single unit
Person Preferred Name

Reddy, N. Srinivasa

creator

Physical Description

pdf
4 p.
PURL
http://purl.flvc.org/FCLA/DT/3164111
Title Plain
Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea
URL
http://purl.flvc.org/FCLA/DT/3164111
Origin Information

American Chemical Society and American Society of Pharmacognosy
2005
single unit
Title
Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea
Other Title Info

Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea