The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50103a029. This article may be cited as: Mierzwa, R., King, A., Conover, M. A., Tozzi, S., Puar, M. S., Patel, M., Coval, S. J., & Pomponi, S. A. (1994). Verongamine, a novel bromotyrosine derived histamine H3-antagonist from the marine sponge Verongula gigantea. Journal of Natural Products, 57(1), 175-177. doi:10.1021/np50103a029
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #993.