Wiedendiol-A and -B, novel sesquiterpene-hydroquinones which inhibit cholesteryl ester transfer protein (CETP), have been isolated from the marine sponge Xestospongia wiedenmayeri. Additional related marine natural products were also evaluated for CETP inhibition. Compounds that inhibit the activity of CETP may find utility as antiatherosclerosis therapy.
This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/0960894X and may be cited as: Coval, S. J., Conover, M. A., Mierzwa, R., King, A., Puar, M. S., Phife, D. W., Pai, J.-K., Burrier, R. E., Ahn, H.-S., Boykow, G. C., Patel, M., & Pomponi, S. A. (1995). Wiedendiol-A and -B, Cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri. Bioorganic & Medicinal Chemistry Letters, 5(6), 605-610. doi:10.1016/0960-894X(95)00081-4
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1067.