The sustainable supply of marine-derived bioactive compounds to meet demands for pre-clinical and clinical evaluation is a major consideration in drug development strategies. It is also a concern to environmental resource managers, particularly since conservation of genetic resources may preclude harvesting as a bulk supply strategy. Our research addresses this need by focusing on in vitro production of antitumor compounds through cell culture of the source organisms. Our objectives are: to establish cultures of bioactive marine invertebrates that can be used as models to study in vitro production of antitumor compounds and the factors which control expression of their production; to provide bulk supplies of these compounds through in vitro production; and to produce new structural analogs via manipulation of culture conditions.
Member of
Contributors
Publisher
Plenum Press
Date Issued
1998
Note
Language
Type
Genre
Form
Extent
5 p.
Subject (Topical)
Identifier
FA00007238
Additional Information
The sustainable supply of marine-derived bioactive compounds to meet demands for pre-clinical and clinical evaluation is a major consideration in drug development strategies. It is also a concern to environmental resource managers, particularly since conservation of genetic resources may preclude harvesting as a bulk supply strategy. Our research addresses this need by focusing on in vitro production of antitumor compounds through cell culture of the source organisms. Our objectives are: to establish cultures of bioactive marine invertebrates that can be used as models to study in vitro production of antitumor compounds and the factors which control expression of their production; to provide bulk supplies of these compounds through in vitro production; and to produce new structural analogs via manipulation of culture conditions.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1255
This manuscript is an author version with the final publication available
and may be cited as: Pomponi, S. A., Willoughby, R., Wright, A. E., Pecorella, C., Sennett, S. H., Lopez,
J., & Samples, G. (1998). In vitro production of marine-derived antitumor compounds. In Y. Le Gal &
H. O. Halverson (Eds.), New developments in marine biotechnology (pp. 73-76). New York, NY: Plenum
Press.
and may be cited as: Pomponi, S. A., Willoughby, R., Wright, A. E., Pecorella, C., Sennett, S. H., Lopez,
J., & Samples, G. (1998). In vitro production of marine-derived antitumor compounds. In Y. Le Gal &
H. O. Halverson (Eds.), New developments in marine biotechnology (pp. 73-76). New York, NY: Plenum
Press.
Date Backup
1998
Date Text
1998
DOI
10.1007/978-1-4757-5983-9_15
Date Issued (EDTF)
1998
Extension
FAU
IID
FA00007238
Organizations
Attributed name: Wright, Amy E.
Person Preferred Name
Pomponi, Shirley A.
spomponi@fau.edu
Physical Description
5 p.
Title Plain
In vitro production of marine-derived antitumor compounds
Origin Information
1998
Plenum Press
New York, NY
Place
New York, NY
Title
In vitro production of marine-derived antitumor compounds
Other Title Info
In vitro production of marine-derived antitumor compounds