Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.

Member of
HBOI Faculty Contributions
Contributors
Horton, P. A.
Longley, Ross E.
Publisher
Birkhauser Verlag
Date Issued
1994
Note

Staurosporine aglycone (K252-c) (compound1) and arcyriaflavin A (2) were isolated from a specimen of the marine ascidian,Eudistoma sp., collected off the coast of West Africa. In addition to expressing micromolar and submicromolar inhibition of enzyme activity against seven protein kinase C isoenzymes and inhibition of proliferation of the human lung cancer A549 and P388 murine leukemia cell lines,1 also inhibited cell adhesion of the EL-4.IL-2 cell line and expressed activity in the K562 bleb and neutrophil assays.

Language
English
Type
Text
Genre
article
Form
pdf
Extent
4 p.
Subject (Topical)
Ascidians
Sea squirts
Protein kinase C
Cytotoxins
Indoles
Carbazoles
Identifier
FA00007230
Additional Information
Staurosporine aglycone (K252-c) (compound1) and arcyriaflavin A (2) were isolated from a specimen of the marine ascidian,Eudistoma sp., collected off the coast of West Africa. In addition to expressing micromolar and submicromolar inhibition of enzyme activity against seven protein kinase C isoenzymes and inhibition of proliferation of the human lung cancer A549 and P388 murine leukemia cell lines,1 also inhibited cell adhesion of the EL-4.IL-2 cell line and expressed activity in the K562 bleb and neutrophil assays.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1022
This manuscript is an author version with the final publication
available and may be cited as: Horton, P. A., Longley, R. E., McConnell, O. J., & Ballas, L. M. (1994).
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.
Experientia, 50(9), 843-845.
Date Backup
1994
Date Text
1994
DOI
10.1007/BF01956468
Date Issued (EDTF)
1994
Extension


FAU

IID
FA00007230
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

Horton, P. A.
Physical Description

pdf
4 p.
PURL
http://purl.flvc.org/fau/fd/FA00007230
Title Plain
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.
URL
http://purl.flvc.org/fau/fd/FA00007230
Origin Information

1994
Birkhauser Verlag

Basel, Switzerland

Place

Basel, Switzerland
Title
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.
Other Title Info

Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.