A new cytotoxic sterol methoxymethyl ether from a deep water marine sponge Scleritoderma sp. cf. paccardi

24(R)-Methyl-5α-cholest-7-enyl 3β-methoxymethyl ether (1), a new sterol ether, has been isolated from a deep-water marine sponge Scleritoderma sp. cf. paccardi. Compound 1 exhibited in vitro cytotoxicity against the cultured murine P-388 tumor cell line with an IC50 of 2.3 μg/mL. The isolation and structure elucidation of 1 by NMR spectroscopy is described.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np9600311. This article may be cited as: Gunasekera, S. P., Kelly-Borges, M., & Longley, R. E. (1996). A new cytotoxic sterol methoxymethyl ether from a deep water marine sponge Scleritoderma sp. cf. paccardi. Journal of Natural Products, 59(2), 161-162. doi:10.1021/np9600311

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1117.