Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University Digital Library
Date Issued
2011
EDTF Date Created
2011
Description
T-lymphocytes develop from bone marrow derived hematopoietic stem cells (HSCs) and
mature in the thymus, where they participate in reciprocal signaling with thymic stromal
cells. The thymic developmental stages are well characterized, but only a few intrathymic
signals that influence the development of T-lymphocytes have been identified. Previous
microarray experiments revealed interleukin-17A (IL-17A) and its receptor (IL-17RA) as
a possible stromal-lymphoid signal. In this study, an IL-17RA-/- knockout was used to
determine whether the IL-17RA gene has a role in T-lymphocyte maturation. We made
competitive bone marrow chimeras and analyzed the percentage of donor wildtype and
mutant HSCs present in the bone marrow, and compared it to the percentage of a
particular blood cell type that developed from these donor HSCs. We found that IL-17RA
influences the maturation of T-lymphocytes, but does not affect the development of other
immune cells such as B-lymphocytes, macrophages, and granulocytes.
mature in the thymus, where they participate in reciprocal signaling with thymic stromal
cells. The thymic developmental stages are well characterized, but only a few intrathymic
signals that influence the development of T-lymphocytes have been identified. Previous
microarray experiments revealed interleukin-17A (IL-17A) and its receptor (IL-17RA) as
a possible stromal-lymphoid signal. In this study, an IL-17RA-/- knockout was used to
determine whether the IL-17RA gene has a role in T-lymphocyte maturation. We made
competitive bone marrow chimeras and analyzed the percentage of donor wildtype and
mutant HSCs present in the bone marrow, and compared it to the percentage of a
particular blood cell type that developed from these donor HSCs. We found that IL-17RA
influences the maturation of T-lymphocytes, but does not affect the development of other
immune cells such as B-lymphocytes, macrophages, and granulocytes.
Language
Type
Genre
Form
Extent
44 p.
Identifier
FA00003578
Rights
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Additional Information
Includes bibliography.
Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2011.
Florida Atlantic University Digital Library Collections
Date Backup
2011
Date Created Backup
2011
Date Text
2011
Date Created (EDTF)
2011
Date Issued (EDTF)
2011
Extension
FAU
IID
FA00003578
Organizations
Attributed name: Harriet L. Wilkes Honors College
Attributed name: Florida Atlantic University
Person Preferred Name
Gopaldas, Manesh
author
Harriet L. Wilkes Honors College
Physical Description
online resource
44 p.
Title Plain
The Role of IL-17 in T-Cell Development
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2011
2011
Florida Atlantic University Digital Library
Boca Raton, Fla.
Place
Boca Raton, Fla.
Title
The Role of IL-17 in T-Cell Development
Other Title Info
The Role of IL-17 in T-Cell Development