Nortopsentins A, B, and C. Cytotoxic and antifungal imidazolediylbis [indoles] from the sponge Spongosorites ruetzleri

Member of
HBOI Faculty Contributions
Contributors
Sakemi, S.
Sun, H. H.
Publisher
American Chemical Society
Date Issued
1991
Note

Three novel cytotoxic and antifungal alkaloids, nortopsentins A (l), B (2), and C (3), along with two known compounds, topentin (4) and bromotopsentin (a), were isolated from the Caribbean deepsea sponge Spongwrites ruetzleri. The structures of the nortopsentins were established mainly on the basis of NMR spectro scopic data. The unique imidazolediylbis[indole] skeleton of the nortopsentine demonstrates a new condensation process in tryptophan metabolism. The nortopsentina exhibited in vitro cytotoxicity against P388 cells and antifungal activity against Candida albicans.

Language
English
Type
Text
Genre
article
Extent
5 p.
Subject (Topical)
Sponges
Indole Alkaloids
Marine natural products
Identifier
3332983
Additional Information
Three novel cytotoxic and antifungal alkaloids, nortopsentins A (l), B (2), and C (3), along with two known compounds, topentin (4) and bromotopsentin (a), were isolated from the Caribbean deepsea sponge Spongwrites ruetzleri. The structures of the nortopsentins were established mainly on the basis of NMR spectro scopic data. The unique imidazolediylbis[indole] skeleton of the nortopsentine demonstrates a new condensation process in tryptophan metabolism. The nortopsentina exhibited in vitro cytotoxicity against P388 cells and antifungal activity against Candida albicans.
This document is the accepted manuscript version of a published work that appeared in final form in The Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00013a044. This article may be cited as: Sakemi, S., & Sun, H. H. (1991). Nortopsentins A, B, and C. Cytotoxic and antifungal imidazolediylbis [indoles] from the sponge Spongosorites ruetzleri. The Journal of Organic Chemistry, 56(13), 4304-4307. doi:10.1021/jo00013a044
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #840.
Date Backup
1991
Date Text
1991
DOI
10.1021/jo00013a044
Date Issued (EDTF)
1991
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing12091", creator="creator:BCHANG", creation_date="2012-02-22 07:58:53", modified_by="super:FAUDIG", modification_date="2014-02-13 10:51:14"

IID
FADT3332983
Issuance
single unit
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

Sakemi, S.

creator

Physical Description

pdf
5 p.
PURL
http://purl.flvc.org/FCLA/DT/3332983
Title Plain
Nortopsentins A, B, and C. Cytotoxic and antifungal imidazolediylbis [indoles] from the sponge Spongosorites ruetzleri
URL
http://purl.flvc.org/FCLA/DT/3332983
Origin Information

American Chemical Society
1991
single unit
Title
Nortopsentins A, B, and C. Cytotoxic and antifungal imidazolediylbis [indoles] from the sponge Spongosorites ruetzleri
Other Title Info

Nortopsentins A, B, and C. Cytotoxic and antifungal imidazolediylbis [indoles] from the sponge Spongosorites ruetzleri