Note
Attempts to understand the mechanism by which amphetamine affects feeding have generally focused on the acute, ``anorexigenic'' effect of the drug. Neuroanatomical and neuropharmacological studies have provided information about the neural structures and neurotransmitter systems that mediate this effect and behavioral studies have characterized how the drug disrupts the microstructure of feeding behavior. What is often ignored in these studies, however, is that the anorexigenic effect of amphetamine is transient, being subject to the development of tolerance when the drug is administered chronically.