Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2018
EDTF Date Created
2018
Description
Pancreatic cancer is an abhorrent malignancy with limited diagnostics and
response to drug therapy. It is believed that noncoding RNAs (ncRNAs) will further the
understanding behind the mechanisms of pancreatic cancer development and progression,
providing a novel approach for drug development and biomarker discovery. Therefore, a
database of pancreatic cancer ncRNAs was established using bioinformatics and text
mining approaches. These ncRNAs were characterized for RNA expression, copy number
variation, disease association, single nucleotide polymorphisms, secretome analysis, and
identification of protein targets. Exosomal proteins and ncRNA identified through this
study provide the basis for noninvasive diagnostic potential. Additionally, a secreted
microRNA, MIR3620, emerged from this study as a potential prognostic and diagnostic
biomarker for pancreatic cancer. By analyzing MIR3620 and its protein targets, a
mechanism of regulation for these genes in contributing to the progression and
development of pancreatic cancer was established.
response to drug therapy. It is believed that noncoding RNAs (ncRNAs) will further the
understanding behind the mechanisms of pancreatic cancer development and progression,
providing a novel approach for drug development and biomarker discovery. Therefore, a
database of pancreatic cancer ncRNAs was established using bioinformatics and text
mining approaches. These ncRNAs were characterized for RNA expression, copy number
variation, disease association, single nucleotide polymorphisms, secretome analysis, and
identification of protein targets. Exosomal proteins and ncRNA identified through this
study provide the basis for noninvasive diagnostic potential. Additionally, a secreted
microRNA, MIR3620, emerged from this study as a potential prognostic and diagnostic
biomarker for pancreatic cancer. By analyzing MIR3620 and its protein targets, a
mechanism of regulation for these genes in contributing to the progression and
development of pancreatic cancer was established.
Language
Type
Form
Extent
178 p.
Subject (Topical)
Identifier
FA00013086
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2018.
FAU Electronic Theses and Dissertations Collection
Date Backup
2018
Date Created Backup
2018
Date Text
2018
Date Created (EDTF)
2018
Date Issued (EDTF)
2018
Extension
FAU
IID
FA00013086
Organizations
Attributed name: Florida Atlantic University
Attributed name: Charles E. Schmidt College of Science
Attributed name: Department of Biological Sciences
Person Preferred Name
Makler, Amy
author
Graduate College
Physical Description
application/pdf
178 p.
Title Plain
Noncoding RNAs as novel pancreatic cancer targets
Use and Reproduction
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2018
2018
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Noncoding RNAs as novel pancreatic cancer targets
Other Title Info
Noncoding RNAs as novel pancreatic cancer targets