New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi

Member of
HBOI Faculty Contributions
Contributors
Koehn, F. E.
Gunasekera, M.
Cross, S. S.
Publisher
American Chemical Society
Date Issued
1991
Note

During our ongoing program to isolate novel antiviral marine natural products, we have found that extracts of the marine sponge Petrosia weinbergi show in vitro activity against feline leukemia virus (FELV), mouse influenza virus (PR8), and mouse coronavirus (A59).3 We report here the isolation and structure elucidation of orthoesterol disulfates A (1a), B (1b), and C (1C), three new antiviral sterol disulfate ortho esters. We believe these to be the first reported examples in the steroid class of this particular combination of functionalities.

Language
English
Type
Text
Genre
article
Extent
5 p.
Subject (Topical)
Sponges
Sterols
Marine natural products
Antiviral agents
Identifier
3332977
Additional Information
During our ongoing program to isolate novel antiviral marine natural products, we have found that extracts of the marine sponge Petrosia weinbergi show in vitro activity against feline leukemia virus (FELV), mouse influenza virus (PR8), and mouse coronavirus (A59).3 We report here the isolation and structure elucidation of orthoesterol disulfates A (1a), B (1b), and C (1C), three new antiviral sterol disulfate ortho esters. We believe these to be the first reported examples in the steroid class of this particular combination of functionalities.
This document is the accepted manuscript version of a published work that appeared in final form in The Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00003a080. This article may be cited as: Koehn, F. E., Gunasekera, M., & Cross, S. S. (1991). New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi. The Journal of Organic Chemistry, 56(3), 1322-1325. doi:10.1021/jo00003a080
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #811.
Date Backup
1991
Date Text
1991
DOI
10.1021/jo00003a080
Date Issued (EDTF)
1991
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing12088", creator="creator:BCHANG", creation_date="2012-02-22 07:56:42", modified_by="super:FAUDIG", modification_date="2014-02-13 10:49:20"

IID
FADT3332977
Issuance
single unit
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

Koehn, F. E.

creator

Physical Description

pdf
5 p.
PURL
http://purl.flvc.org/FCLA/DT/3332977
Title Plain
New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi
URL
http://purl.flvc.org/FCLA/DT/3332977
Origin Information

American Chemical Society
1991
single unit
Title
New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi
Other Title Info

New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi