Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the structurally related discodermolide, synthesised by a late-stage diversification strategy and evaluated in vitro for growth inhibition against a range of human cancer cell lines, including those known to exhibit Taxol-resistance (AsPC-1, DLD-1, PANC-1, NCI/ADR).
This is the author’s version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version has been published at http://www.elsevier.com/ and may be cited as: Paterson, Ian, Nicola M. Gardner, Katrine G. Poullennec, and Amy E. Wright (2007) Synthesis and biological evaluation of novel analogues of dictyostatin, Bioorganic & Medicinal Chemistry M Letters 17(9):2443‐2447 doi:10.1016/j.bmcl.2007.02.031
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1675.