Antitumoractivity and mechanism of action of the novel marine natural products mycalamide-A and -B andonnamide

Three novel heterocyclic compounds, mycalamide-A and -B and onnamide, were isolated from Mycale sp. and Theonella sp. sponges collected in New Zealand and Okinawan waters. Each exhibited potent in vitro toxicity and in vivo efficacy against murine and human tumor cells.

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 699

This manuscript is an author version with
the final publication available and may be cited as: Burres, N. S., & Clement, J. J. (1989). Antitumor
activity and mechanism of action of the novel marine natural products mycalamide-A and -B and
onnamide. Cancer Research, 49(11), 2935-2940.