Bis(sulfato)-cyclosiphonodictyol A, a new disulfated sesquiterpene-hydroquinone from a deep water collection of the marine sponge Siphonodictyon coralliphagum

A new compound, bis(sulfato)-cyclosiphonodictyol A [1], which inhibits the binding of [3H]-LTB4 to intact human neutrophils with an IC50 value of 44 microM, was isolated from the sponge Siphonodictyon coralliphagum. The sponge was collected using the Johnson-Sea-Link manned submersible at a depth of 195 feet in the Bahamas. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50120a024. This article may be cited as: Killday, K. B., Wright, A. E., Jackson, R. H., & Sills, M. A. (1995). Bis(sulfato)-cyclosiphonodictyol A, a new disulfated sesquiterpene-hydroquinone from a deep water collection of the marine sponge Siphonodictyon coralliphagum. Journal of Natural Products, 58(6), 958-960. doi:10.1021/np50120a024

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1077.