Biogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolites

From a Verongid sponge, family Aplysinellidae and most likely a member of an undescribed genus, we have isolated respectable quantities of a bromotyramine derivative, moloka’iamine (1) and of puupehenone (5) related compounds. When broken apart, the animal emits hydrogen cyanide. The structures were determined spectrally and by comparison with published data.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00076a012. This article may be cited as: Hamann, M. T., Scheuer, P. J., & Kelly-Borges, M. (1993). Biogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolites. Journal of Organic Chemistry, 58(24), 6565-6569. doi:10.1021/jo00076a012

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #962.