Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2007
EDTF Date Created
2007
Description
Ocular neovascularization (NV), the development of new blood vessels in the eye, occurs
when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV
may lead to photoreceptor loss and or blindness, as it does in age-related macular
degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy.
We tested the hypothesis that the anti-inflammatory cytokine, interleukin-10 (IL-10);
can reduce inflammation and block NV in the affected areas of the retina. The mouse
ROP model was used for this study of NV. Seven day old neonates stayed in 75% oxygen
for five days, then were given intraocular injection of IL-100 and NV was evaluated after
seven days in room air. Controls were uninjected contralateral eyes. IL-l 0 strongly
inhibited NV without affecting intra-retinal vessels. The selective inhibition of IL-10 on NV suggest a possible therapeutic use in infants with ROP, in diabetic retinopathy, and
possibly, in AMD where inflammation is a risk factor.
when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV
may lead to photoreceptor loss and or blindness, as it does in age-related macular
degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy.
We tested the hypothesis that the anti-inflammatory cytokine, interleukin-10 (IL-10);
can reduce inflammation and block NV in the affected areas of the retina. The mouse
ROP model was used for this study of NV. Seven day old neonates stayed in 75% oxygen
for five days, then were given intraocular injection of IL-100 and NV was evaluated after
seven days in room air. Controls were uninjected contralateral eyes. IL-l 0 strongly
inhibited NV without affecting intra-retinal vessels. The selective inhibition of IL-10 on NV suggest a possible therapeutic use in infants with ROP, in diabetic retinopathy, and
possibly, in AMD where inflammation is a risk factor.
Language
Type
Form
Extent
47 p.
Subject (Topical)
Identifier
FA00000833
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2007.
FAU Electronic Theses and Dissertations Collection
Charles E. Schmidt College of Medicine
Date Backup
2007
Date Created Backup
2007
Date Text
2007
Date Created (EDTF)
2007
Date Issued (EDTF)
2007
Extension
FAU
IID
FA00000833
Organizations
Attributed name: Florida Atlantic University
Person Preferred Name
Solomon, Evertz Stenson
Graduate College
Physical Description
application/pdf
47 p.
Title Plain
Interleukin 10 (IL-10) selectively inhibits neovascularization in the Murine model of Retinopathy of Prematurity
Use and Reproduction
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Origin Information
2007
2007
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Interleukin 10 (IL-10) selectively inhibits neovascularization in the Murine model of Retinopathy of Prematurity
Other Title Info
Interleukin 10 (IL-10) selectively inhibits neovascularization in the Murine model of Retinopathy of Prematurity