Note
Includes bibliography.
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Contributors
Publisher
Florida Atlantic University Digital Library
Date Issued
2011
EDTF Date Created
2011
Description
Prostate cancer has the second highest mortality rate of all cancers in men. The Myc oncoprotein is misregulated in 70% of all cancers, including 70% of prostate cancers, and affects several cancer mechanisms. Myc is able to directly repress the expression of Tristetraprolin (TTP). TTP regulates mRNA stability by binding to select mRNAs.
Furthermore, TTP is able to suppress Myc‐driven B cell lymphoma in mice. In these
studies, cell culture models were used to access the role of Myc-induced repression of
TTP in prostate cancer. Prostate cancer cells lines were identified with inverse expression of Myc and TTP. Additionally, ARE‐containing genes with roles in various cancer mechanisms were differentially expressed in these models. These findings suggest that Myc’s ability to downregulate TTP is important in prostate cancer and provide new avenues for treating Myc‐driven prostate cancer.
Furthermore, TTP is able to suppress Myc‐driven B cell lymphoma in mice. In these
studies, cell culture models were used to access the role of Myc-induced repression of
TTP in prostate cancer. Prostate cancer cells lines were identified with inverse expression of Myc and TTP. Additionally, ARE‐containing genes with roles in various cancer mechanisms were differentially expressed in these models. These findings suggest that Myc’s ability to downregulate TTP is important in prostate cancer and provide new avenues for treating Myc‐driven prostate cancer.
Language
Type
Genre
Form
Extent
47 p.
Identifier
FA00003554
Rights
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Additional Information
Includes bibliography.
Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2011.
Florida Atlantic University Digital Library Collections
Date Backup
2011
Date Created Backup
2011
Date Text
2011
Date Created (EDTF)
2011
Date Issued (EDTF)
2011
Extension
FAU
IID
FA00003554
Organizations
Attributed name: Harriet L. Wilkes Honors College
Attributed name: Florida Atlantic University
Person Preferred Name
Altman, Evan
author
Harriet L. Wilkes Honors College
Physical Description
online resource
47 p.
Title Plain
MYC-induced repression of Tristetraprolin alters the expression of are-containing genes in prostate cancer
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2011
2011
Florida Atlantic University Digital Library
Boca Raton, Fla.
Place
Boca Raton, Fla.
Title
MYC-induced repression of Tristetraprolin alters the expression of are-containing genes in prostate cancer
Other Title Info
MYC-induced repression of Tristetraprolin alters the expression of are-containing genes in prostate cancer