Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2008
EDTF Date Created
2008
Description
Fibropapillomatosis (FP) is a devastating pandemic characterized by benign
cutaneous neoplasias that is afflicting marine turtles worldwide. This study evaluated the
expression of HSP72, GRP96, and Bcl-2 in tumor and healthy biopsies. These proteins
are found in high levels in some tumors and prevent apoptosis, allowing tumor cells to
survive. HSP72 and GRP96 are also known to initiate an immune response and may
contribute to the regression often observed in FP tumors. Results were found that
showed all three protective proteins had significantly higher levels in actively growing
tumor tissue compared to healthy tissue. Specifically, cauliflower-like tumors, thought to
be actively growing, were found to have higher levels of HSP72 and GRP96 compared to
healthy skin, whereas smooth tumors, thought to be regressing, did not. These results
offer insight into the molecular mechanisms behind the development of FP tumors and
open a number of avenues for future research.
cutaneous neoplasias that is afflicting marine turtles worldwide. This study evaluated the
expression of HSP72, GRP96, and Bcl-2 in tumor and healthy biopsies. These proteins
are found in high levels in some tumors and prevent apoptosis, allowing tumor cells to
survive. HSP72 and GRP96 are also known to initiate an immune response and may
contribute to the regression often observed in FP tumors. Results were found that
showed all three protective proteins had significantly higher levels in actively growing
tumor tissue compared to healthy tissue. Specifically, cauliflower-like tumors, thought to
be actively growing, were found to have higher levels of HSP72 and GRP96 compared to
healthy skin, whereas smooth tumors, thought to be regressing, did not. These results
offer insight into the molecular mechanisms behind the development of FP tumors and
open a number of avenues for future research.
Language
Type
Form
Extent
78 p.
Subject (Topical)
Identifier
FA00000740
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2008.
Charles E. Schmidt College of Science
FAU Electronic Theses and Dissertations Collection
Date Backup
2008
Date Created Backup
2008
Date Text
2008
Date Created (EDTF)
2008
Date Issued (EDTF)
2008
Extension
FAU
IID
FA00000740
Organizations
Attributed name: Florida Atlantic University
Person Preferred Name
Deming, Alissa C.
Graduate College
Physical Description
application/pdf
78 p.
Title Plain
Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis
Use and Reproduction
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Origin Information
2008
2008
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis
Other Title Info
Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis