Isolation and identification of active principals from the marine sponge Topsentia sp.(Halichon driidae) are described in this paper.In this study, a fraction was identified which bound to the P2Y12 receptor.Fol lowed by bioassay-guided fractionation of this active fraction, one new compound Sch 572423 (2) was discovered in addition to the principal active compound, halistanol sulfate (1).
This is the author’s version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version has been published at http://www.elsevier.com/ and may be cited as Yang, Shu-Wei, Alexei Buevich, Tze-Ming Chan, Michelle Smith, Jean Lachowicz, Shirley A. Pomponi, Amy E.Wright, Ronald Mierzwa, Mahesh Patel, Vincent Gullo, Min Chu (2003) A New Sterol Sulfate, Sch 572423, from a Marine Sponge, Topsentia sp., Bioorganic & Medicinal Chemistry Letters 13: 1791–1794 doi: 10.1016/S0960-894X(03)00260-9
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1558.
The name of author Alexei Buevich was incorrectly spelled Buivich in this journal article and has been corrected in this record.