New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes

Member of
HBOI Faculty Contributions
Contributors
Horton, P. A.
Longley, Ross E.
Kelly-Borges, M.
McConnell, O. J.
Ballas, L. M.
Publisher
American Chemical Society
Date Issued
1994
Note

Three new peroxylactones, plakortolides B [6], C [7], and D [8], and a new peroxyester, epiplakinic acid E methyl ester [9], were isolated and characterized from a previously unstudied marine sponge, Plakinastrella onkodes. A mixture of steroidal peroxides was also found in this organism. Plakortolides B [6] and D [S], and epiplakinic acid E methyl ester 191, were evaluated for biological activity and found to show cytotoxicity against the A549 human lung carcinoma and P388 murine leukemia cell lines, and to effect adhesion in an assay employing the EL-4.E-2 cell line, which correlates with signal transduction activity.

Language
English
Type
Text
Genre
article
Extent
9 p.
Subject (Topical)
Sponges --Research
Marine natural products
Cytotoxin
Identifier
3319074
Additional Information
Three new peroxylactones, plakortolides B [6], C [7], and D [8], and a new peroxyester, epiplakinic acid E methyl ester [9], were isolated and characterized from a previously unstudied marine sponge, Plakinastrella onkodes. A mixture of steroidal peroxides was also found in this organism. Plakortolides B [6] and D [S], and epiplakinic acid E methyl ester 191, were evaluated for biological activity and found to show cytotoxicity against the A549 human lung carcinoma and P388 murine leukemia cell lines, and to effect adhesion in an assay employing the EL-4.E-2 cell line, which correlates with signal transduction activity.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50112a006. This article may be cited as: Horton, P. A., Longley, R. E., Kelly-Borges, M., McConnell, O. J., & Ballas, L. M. (1994). New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes. Journal of Natural Products, 57(10), 1374-1381. doi:10.1021/np50112a006
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1035.
Date Backup
1994
Date Text
1994
DOI
10.1021/np50112a006
Date Issued (EDTF)
1994
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing11299", creator="creator:FAUDIG", creation_date="2011-10-28 13:27:16", modified_by="super:FAUDIG", modification_date="2014-02-12 11:08:46"

IID
FADT3319074
Issuance
single unit
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

Horton, P. A.

creator

Physical Description

pdf
9 p.
PURL
http://purl.flvc.org/FCLA/DT/3319074
Title Plain
New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes
URL
http://purl.flvc.org/FCLA/DT/3319074
Origin Information

American Chemical Society
1994
single unit
Title
New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes
Other Title Info

New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes