Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2015
EDTF Date Created
2015
Description
This study determined the impact of vitamin C dose on genistein-induced apoptosis in LNCaP cancer cells at various treatment regimens in vitro. Although the linear regression of viability assay (MTT) indicated a p-value = 0.11; NBT assay reveal a declining SOD activity during cell death. Apoptosis induction was the main mode of treatment induced cell death. The overall data showed the trend of treatment efficacy as;(Gen 10uM + Vit C 40uM) > (Gen 30uM + Vit C 40uM) > (Gen 70uM + Vit C 40uM) > 10uM genistein > 70uM genistein. The chi-square test for comparing necrosis, apoptosis and life cells showed that Vitamin C could impact genistein-induced apoptosis in LNCaP cells (p = 0.0003). This study forms the basis for in vivo studies of the impact of vitamin C on genistein-induced apoptosis in LNCaP prostate cancer cells.
Language
Type
Form
Extent
118 p.
Subject (Topical)
Identifier
FA00004497
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2015.
FAU Electronic Theses and Dissertations Collection
Date Backup
2015
Date Created Backup
2015
Date Text
2015
Date Created (EDTF)
2015
Date Issued (EDTF)
2015
Extension
FAU
IID
FA00004497
Organizations
Attributed name: Florida Atlantic University
Attributed name: Charles E. Schmidt College of Science
Attributed name: Department of Biological Sciences
Person Preferred Name
Famuyiwa, Toluleke
author
Graduate College
Physical Description
application/pdf
118 p.
Title Plain
Impact of Vitamin C on Genistein-Induced Apoptosis in Prostate Cancer
Use and Reproduction
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2015
2015
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Impact of Vitamin C on Genistein-Induced Apoptosis in Prostate Cancer
Other Title Info
Impact of Vitamin C on Genistein-Induced Apoptosis in Prostate Cancer