Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata

Member of
HBOI Faculty Contributions
Contributors
Biabani, Misbah F.
Gunasekera, Sarath P.
Longley, Ross E.
Wright, Amy E.
Pomponi, Shirley A.
Publisher
Swets & Zeitlinger
Date Issued
2002
Note

Tubercidin (1), a known nucleoside antibiotic, was isolated as the major metabolite from a marine sponge Caulospongia biflabellata. Compound 1 exhibited potent cytotoxic activity against P388 and A549 tumor cells. The isolation, structure elucidation and biological activities of tubercidin (1) are described. This is the first report of the isolation of tubercidin from a marine organism.

Language
English
Type
Text
Genre
article
Extent
3 p.
Subject (Topical)
Demospongiae
Nucleosides --chemistry
Cytotoxins --biosynthesis --congresses
Streptomyces
Antitumor antibiotics
Identifier
2795916
Additional Information
Tubercidin (1), a known nucleoside antibiotic, was isolated as the major metabolite from a marine sponge Caulospongia biflabellata. Compound 1 exhibited potent cytotoxic activity against P388 and A549 tumor cells. The isolation, structure elucidation and biological activities of tubercidin (1) are described. This is the first report of the isolation of tubercidin from a marine organism.
This author manuscript is an electronic version of an article published in Pharmaceutical Biology and may be cited as Biabani, Misbah F., Sarath P. Gunasekera, Ross E. Longley, Amy E. Wright and Shirley A. Pomponi (2002) Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata, Pharmaceutical Biology 40(4):302–303.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1470.
Date Backup
2002
Date Text
2002
DOI
10.1076/phbi.40.4.302.8469
Date Issued (EDTF)
2002
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing8041", creator="creator:SPATEL", creation_date="2010-11-12 10:44:14", modified_by="super:FAUDIG", modification_date="2014-02-10 12:18:21"

IID
FADT2795916
Issuance
single unit
Person Preferred Name

Biabani, Misbah F.

creator

Physical Description

pdf
3 p.
PURL
http://purl.flvc.org/FCLA/DT/2795916
Title Plain
Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata
URL
http://purl.flvc.org/FCLA/DT/2795916
Origin Information

Swets & Zeitlinger
2002
single unit
Title
Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata
Other Title Info

Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata