Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae

Member of
HBOI Faculty Contributions
Contributors
McConnell, O. J.
Longley, Ross E.
Publisher
Birkhauser Verlag
Date Issued
1992
Note

Isometachromin (1), a new sesquiterpene-quinone that is related structurally to metachromin C (2), and the known compounds ilimaquinone (3) and 5-epi-ilimaquinone (4), were isolated from a deep water sponge in the family Spongiidae; the structure of isometachromin was elucidated by spectral methods. Isometachromin exhibits in vitro cytotoxicity against the human lung cancer cell line A549 (IC50 = 2.6 micrograms/ml), but not against P388 murine leukemia (IC 50 > or equal to 10 micrograms/ml) and also exhibits antimicrobial activity.

Language
English
Type
Text
Genre
article
Form
pdf
Extent
3 p.
Subject (Topical)
Sponges
Sesquiterpenes
Cytotoxins
Porifera
Identifier
FA00007220
Additional Information
Isometachromin (1), a new sesquiterpene-quinone that is related structurally to metachromin C (2), and the known compounds ilimaquinone (3) and 5-epi-ilimaquinone (4), were isolated from a deep water sponge in the family Spongiidae; the structure of isometachromin was elucidated by spectral methods. Isometachromin exhibits in vitro cytotoxicity against the human lung cancer cell line A549 (IC50 = 2.6 micrograms/ml), but not against P388 murine leukemia (IC 50 > or equal to 10 micrograms/ml) and also exhibits antimicrobial activity.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 911
This manuscript is an author version with the final publication
available and may be cited as: McConnell, O. J., Longley, R., & Gunasekera, M. (1992).
Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae.
Experientia, 48(9), 891-892.
Date Backup
1992
Date Text
1992
Date Issued (EDTF)
1992
Extension


FAU

IID
FA00007220
Organizations
Attributed name: Gunasekera, M.
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

McConnell, O. J.
Physical Description

pdf
3 p.
PURL
http://purl.flvc.org/fau/fd/FA00007220
Title Plain
Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae
URL
http://purl.flvc.org/fau/fd/FA00007220
Origin Information

1992
Birkhauser Verlag

Basel, Switzerland

Place

Basel, Switzerland
Title
Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae
Other Title Info

Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae