Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.

Member of
HBOI Faculty Contributions
Contributors
Wright, Amy E.
Chen, Ying
Winder, Priscilla L.
Pitts, Tara P.
Pomponi, Shirley A.
Longley, Ross E.
Publisher
American Chemical Society and American Society of Pharmacognosy
Date Issued
2004
Note

Five new marine-derived macrolide compounds, lasonolides C (3), D (4), E (5), F (6), and G (7), have been isolated from the sponge Forcepia sp. along with the parent compound in the series, lasonolide A (1). Their structures were elucidated on the basis of spectral data. Compounds 3-5 inhibit the in vitro proliferation of A-549 human lung adenocarcinoma cells with IC50’s of 0.13, 4.5, and 0.31 µM, respectively. Compounds 3-6 inhibit the in vitro proliferation of PANC-1 human pancreatic carcinoma cells with IC50’s of 0.38, 4.89, 0.57, and 15.6 µM, respectively. Compound 3 inhibits the in vitro proliferation of the NCIADR-RES cell line with an IC50 of 1.12 µM.

Language
English
Type
Text
Genre
article
Extent
6 p.
Subject (Topical)
Macrolide antibiotics
Natural products
Mass spectrometry
Sponges
Stereochemistry
Identifier
3164109
Additional Information
Five new marine-derived macrolide compounds, lasonolides C (3), D (4), E (5), F (6), and G (7), have been isolated from the sponge Forcepia sp. along with the parent compound in the series, lasonolide A (1). Their structures were elucidated on the basis of spectral data. Compounds 3-5 inhibit the in vitro proliferation of A-549 human lung adenocarcinoma cells with IC50’s of 0.13, 4.5, and 0.31 µM, respectively. Compounds 3-6 inhibit the in vitro proliferation of PANC-1 human pancreatic carcinoma cells with IC50’s of 0.38, 4.89, 0.57, and 15.6 µM, respectively. Compound 3 inhibits the in vitro proliferation of the NCIADR-RES cell line with an IC50 of 1.12 µM.
Thisdocument is the accepted manuscript version of a published work that appeared in final formin Journal of Natural Products after peer review and technical editing by the publisher. Toaccess the final edited and published work see http://dx.doi.org/10.1021/np040028e. Thisarticle may be cited as: Wright, A. E., Chen, Y., Winder, P. L., Pitts, T.P., Pomponi, S. A. & andLongley, R. E. (2004). Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp. Journal of Natural Products, 67(8), 1351-1355.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1555.
Date Backup
2004
Date Text
2004
DOI
10.1021/np040028e
Date Issued (EDTF)
2004
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing9356", creator="creator:BCHANG", creation_date="2011-04-25 13:56:55", modified_by="super:FAUDIG", modification_date="2014-02-10 14:23:45"

IID
FADT3164109
Issuance
single unit
Person Preferred Name

Wright, Amy E.

creator

awrigh33@fau.edu
Physical Description

pdf
6 p.
PURL
http://purl.flvc.org/FCLA/DT/3164109
Title Plain
Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
URL
http://purl.flvc.org/FCLA/DT/3164109
Origin Information

American Chemical Society and American Society of Pharmacognosy
2004
single unit
Title
Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
Other Title Info

Lasonolides C—G, Five New Lasonolide Compounds from the Sponge Forcepia sp.