Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines

Member of
HBOI Faculty Contributions
Contributors
Guzman, Esther A.
Johnson, J. D.
Carrier, M. K.
Meyer, C. I.
Pitts, Tara P.
Gunasekera, Sarath P.
Wright, Amy E.
Publisher
Lippincott, Williams & Wilkins
Date Issued
2009
Note

Given our interest in
finding new therapies for pancreatic cancer, we sought to
determine whether the known cytotoxic activity of the
batzellines extended to pancreatic cancer cell lines. The
batzellines are pyrroloiminoquinones alkaloids obtained
from the deep-water Caribbean sponge Batzella sp (family
Esperiopsidae, order Poecilosclerida). We show here that
batzellines exhibit selective cytotoxicity towards the
pancreatic cancer cell lines AsPC-1, Panc-1, BxPC-3, and
MIA PaCa2 compared with the normal African green
monkey kidney epithelial cell line Vero.

Language
English
Type
Text
Genre
article
Form
pdf
Extent
8 p.
Subject (Topical)
Pancreas--Cancer
Marine natural products
Drug Discovery
Sponges--Caribbean Sea
Mechanism of action (Biochemistry)
Identifier
FA00007114
Additional Information
Given our interest in
finding new therapies for pancreatic cancer, we sought to
determine whether the known cytotoxic activity of the
batzellines extended to pancreatic cancer cell lines. The
batzellines are pyrroloiminoquinones alkaloids obtained
from the deep-water Caribbean sponge Batzella sp (family
Esperiopsidae, order Poecilosclerida). We show here that
batzellines exhibit selective cytotoxicity towards the
pancreatic cancer cell lines AsPC-1, Panc-1, BxPC-3, and
MIA PaCa2 compared with the normal African green
monkey kidney epithelial cell line Vero.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1715
This manuscript is an author version with the final
publication available and may be cited as: Guzman, E. A., Johnson, J. D., Carrier, M. K., Meyer, C. I.,
Pitts, T. P., Gunasekera, S. P., & Wright, A. E. (2009). Selective cytotoxic activity of the marine derived
batzelline compounds against pancreatic cancer cell lines. Anti-Cancer Drugs, 20(2), 149-155.
doi:10.1097/CAD.0b013e32831fa39e
Date Backup
2009
Date Text
2009
DOI
10.1097/CAD.0b013e32831fa39e
Date Issued (EDTF)
2009
Extension


FAU

IID
FA00007114
Person Preferred Name

Guzman, Esther A.
eguzman9@fau.edu
Physical Description

pdf
8 p.
PURL
http://purl.flvc.org/fau/fd/FA00007114
Title Plain
Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines
URL
http://dx.doi.org/10.1097/CAD.0b013e32831fa39e
Origin Information

2009
Lippincott, Williams & Wilkins

Philadelphia

Place

Philadelphia
Title
Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines
Other Title Info

Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines