Note
by Neeta Kumari.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2012
Description
We employed three genotypes of GAD 65, wildtype (GAD 65 +/+), heterozygous (GAD 65 +/-) and knockout (GAD 65 -/-) to investigate the role of GAD 65 in survival of pancreatic islets. We analyzed the mRNA expression of pro-survival proteins including Bcl2 and Bax in pancreas of wildtype, heterozygous and knockout using Reverse Transcriptase Polymerase Chain Reaction (RTPCR). The level of expression of Bcl2 mRNA was down regulated in knockout mice pancreas and Bax to Bcl2 ratio was found higher in knockout mice pancreas suggesting higher cell death rate. However, further studies are required to recognize and understand the specific connections between apoptotic pathways and GAD 65 in pancreatic islets.
Language
Type
Form
Extent
ix, 37, [vi] p. : ill. (some col.)
Subject (Topical)
Identifier
794671814
OCLC Number
794671814
Additional Information
by Neeta Kumari.
Thesis (M.S.)--Florida Atlantic University, 2012.
Includes bibliography.
Electronic reproduction. Boca Raton, Fla., 2012. Mode of access: World Wide Web.
Date Backup
2012
Date Text
2012
Date Issued (EDTF)
2012
Extension
FAU
FAU
admin_unit="FAU01", ingest_id="ing12888", creator="creator:BCHANG", creation_date="2012-06-11 14:23:44", modified_by="super:SPATEL", modification_date="2012-06-11 14:58:00"
IID
FADT3342206
Organizations
Attributed name: Charles E. Schmidt College of Medicine
Attributed name: Department of Biomedical Science
Person Preferred Name
Kumari, Neeta.
Graduate College
Physical Description
electronic
ix, 37, [vi] p. : ill. (some col.)
Title Plain
GAD 65 and its role in pancreatic tissue survival
Use and Reproduction
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
Boca Raton, Fla.
Florida Atlantic University
2012
Place
Boca Raton, Fla.
Title
GAD 65 and its role in pancreatic tissue survival
Other Title Info
GAD 65 and its role in pancreatic tissue survival