Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2019
EDTF Date Created
2019
Description
The causes of autism spectrum disorder (ASD) are not all known, but it is suspected that the serotonin transporter (SERT) plays an important role for some subjects with ASD. Mutations in the SLC6A4 gene, that encodes SERT, including the Ala56 mutation (Gly56Ala), have been found in some autism patients. This mutation makes the transporter more active and reduces the probability of serotonergic neurotransmission in the brain, which is linked to behavioral changes that are associated with core domain deficits of ASD 1.
Depression also has been linked to decreases in the availability of serotonin (5-hydroxytryptamine; 5-HT) in the central nervous system (CNS), and is associated with reduced hippocampal neurogenesis. Selective serotonin reuptake inhibitors (SSRIs), drugs used to block SERTs, are used to treat depression and/or anxiety by inhibiting SERT to increase synaptic 5-HT levels.
Depression also has been linked to decreases in the availability of serotonin (5-hydroxytryptamine; 5-HT) in the central nervous system (CNS), and is associated with reduced hippocampal neurogenesis. Selective serotonin reuptake inhibitors (SSRIs), drugs used to block SERTs, are used to treat depression and/or anxiety by inhibiting SERT to increase synaptic 5-HT levels.
Language
Type
Form
Extent
78 p.
Subject (Topical)
Identifier
FA00013297
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2019.
FAU Electronic Theses and Dissertations Collection
Date Backup
2019
Date Created Backup
2019
Date Text
2019
Date Created (EDTF)
2019
Date Issued (EDTF)
2019
Extension
FAU
IID
FA00013297
Organizations
Attributed name: Florida Atlantic University
Attributed name: Charles E. Schmidt College of Science
Attributed name: Department of Biological Sciences
Person Preferred Name
Di Mase, Julieta Maria
author
Graduate College
Physical Description
application/pdf
78 p.
Title Plain
Hippocampal neurogenesis in the SERT ALA56 mouse model to autism
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2019
2019
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Hippocampal neurogenesis in the SERT ALA56 mouse model to autism
Other Title Info
Hippocampal neurogenesis in the SERT ALA56 mouse model to autism