ADVANCEMENTS IN GLIOBLASTOMA CANCER TREATMENT AND COMPREHENSIVE STUDY OF FIVE AUTHENTIC GLIOBLASTOMA PATIENTS

Glioblastoma multiforme (GBM) is an aggressive and highly resistant brain tumour, necessitating advanced treatment approaches to improve patient outcomes. This thesis provides a comprehensive review of recent advancements in GBM treatment, including innovations in treatment planning, radiation therapy, and their impacts on patient survival. The study also involves a detailed analysis of five GBM patients, examining critical dosimetric and radiobiological parameters, including Dose Volume Histogram, CT and MRI Images, T1, T2, T3 and T4 images. These parameters are analyzed using key radiobiological models, such as the linear-quadratic model, and factors like α/β, dose per fraction, and survival fractions. Through this data analysis, the study aims to evaluate the effectiveness of the treatment protocols and their impact on tumour control probability (TCP) and normal tissue complication probability (NTCP). The results will contribute to the understanding of GBM radiotherapy outcomes and provide insights for optimizing future treatment strategies.