From our efforts to identify antineoplastic compounds from marine organisms we have isolated and identified puupehenone (l), a cytotoxic sesquiterpene-methylene quinone, from a deep water sponge, Strongylophora hartmani van Soest, (family Petrosiidae)1 (2). Puupehenone was isolated previously from an Hawaiian and Eniwetok Atoll species of the genus Heteronema (l), and a Tahitian sponge, Hyrtios eubnamma (3). Neither the halopuupehenones (l), bispuupehenone (3), nor the stronglyophorines, which are meroditerpenoids isolated from Stronglyophora durissima (4), were detected in S. hartmani.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50050a064. This article may be cited as: Kohmoto, S., McConnell, O. J., Wright, A., Koehn, F., Thompson, W., Lui, M., & Snader, K. M. (1987). Puupehenone, a cytotoxic metabolite from a deep water marine sponge, Stronglyophora hartmani. Journal of Natural Products, 50(2), 336. doi:10.1021/np50050a064
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #579.