Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide

Member of
HBOI Faculty Contributions
Contributors
Zhang, L.-H.
Longley, Ross E.
Koehn, F. E.
Publisher
Elsevier B.V.
Date Issued
1997
Note

The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mixed lymphocyte reaction (IC50 = 5.0 nM), anti-IgM (μ-chain specific) (IC50 = 10.0 nM), and phorbol 12-myristate 13-acetate plus ionomycin (IC50 = 5.8 nM) stimulation of murine splenocytes were all similarly suppressed by microcolin A. The inhibitory activity of microcolin A was time-dependent and reversible and was not associated with a reduction in cell viability.

Language
English
Type
Text
Genre
article
Extent
13 p.
Subject (Topical)
Proliferation
Immunosuppressive agents
Blue-green algae
Oligopeptides
Identifier
3331918
Additional Information
The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mixed lymphocyte reaction (IC50 = 5.0 nM), anti-IgM (μ-chain specific) (IC50 = 10.0 nM), and phorbol 12-myristate 13-acetate plus ionomycin (IC50 = 5.8 nM) stimulation of murine splenocytes were all similarly suppressed by microcolin A. The inhibitory activity of microcolin A was time-dependent and reversible and was not associated with a reduction in cell viability.
This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00243205 and may be cited as: Zhang, L.-H., Longley, R. E., & Koehn, F. E. (1997). Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide. Life Sciences, 60(10), 751-762. doi:10.1016/S0024-3205(96)00645-5
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1162.
Date Backup
1997
Date Text
1997
DOI
10.1016/S0024-3205(96)00645-5
Date Issued (EDTF)
1997
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing11847", creator="creator:BCHANG", creation_date="2012-01-12 08:20:38", modified_by="super:FAUDIG", modification_date="2014-02-13 08:53:07"

IID
FADT3331918
Issuance
single unit
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

Zhang, L.-H.

creator

Physical Description

pdf
13 p.
PURL
http://purl.flvc.org/FCLA/DT/3331918
Title Plain
Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide
URL
http://purl.flvc.org/FCLA/DT/3331918
Origin Information

Elsevier B.V.
1997
single unit
Title
Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide
Other Title Info

Antiproliferative and immunosuppressive properties of Microcolin A, a marine-derived lipopeptide