Sesquiterpene-derived metabolites from the deep water marine sponge Poecillastra sollasi

Six sesquiterpene-derived compounds, 1-6, which we call sollasins a-f, have been isolated from a deep water specimen of the sponge Poecillastra sollasi. The structures were elucidated by comparison of spectral data to related metabolites and confirmed using spectroscopic methods. The compounds inhibit the growth of the pathogenic fungi Candida albicans and Cryptococcus neoformans and the P-388 and A-549 tumor cell lines.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50094a008. This article may be cited as: Killday, K. B., Longley, R., McCarthy, P. J., Pomponi, S. A., & Wright, A. E. (1993). Sesquiterpene-derived metabolites from the deep water marine sponge Poecillastra sollasi. Journal of Natural Products, 56(4), 500-507. doi:10.1021/np50094a008

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #946.