Note
Thesis (M.S.)--Florida Atlantic University, 1999.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
1999
Description
The ecteinascidins are a family of marine derived alkaloids with potent antitumor activity. Ecteinascidins 743 and 729 are the prime targets due to their superior antitumor activity. beta-Mercaptopyruvic acid is a proposed intermediate in the biosynthesis of ecteinascidins 743/729. A novel synthesis of beta-mercaptopyruvic acid using an enzymatic system was achieved. This was accomplished by trapping the equilibrium between beta-mercaptopyruvic acid and 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate using oxidative deamination of cysteine by amino acid oxidase.
Language
Type
Form
Extent
66 p.
Subject (Topical)
Identifier
9780599540545
ISBN
9780599540545
Additional Information
Thesis (M.S.)--Florida Atlantic University, 1999.
Date Backup
1999
Date Text
1999
Date Issued (EDTF)
1999
Extension
FAU
FAU
admin_unit="FAU01", ingest_id="ing1508", creator="staff:fcllz", creation_date="2007-07-19 04:53:33", modified_by="staff:fcllz", modification_date="2011-01-06 13:09:24"
IID
FADT15725
Issuance
monographic
Organizations
Attributed name: Florida Atlantic University
Person Preferred Name
Fawehinmi, Hafusat Abosede
Graduate College
Physical Description
66 p.
application/pdf
Title Plain
efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
1999
monographic
Boca Raton, Fla.
Florida Atlantic University
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis
Other Title Info
An
efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis