Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella

34-Sulfatobastadin 13 [1] was isolated from the sponge Ianthella sp. Its structure was elucidated by nmr techniques and chemical transformation to bastadin 13 [2]. Compound 1 weakly inhibited binding to the endothelin A receptor (ETA), while compound 2 inhibited growth of Bacillus subtilis.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50099a026. This article may be cited as: Gulavita, N. K., Wright, A. E., McCarthy, P. J., Pomponi, S. A., Kelly-Borges, M., Chin, M. & Sills, M. W. (1993). Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella. Journal of Natural Products, 56(9), 1613-1617. doi:10.1021/np50099a026

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #954.