Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakenss

Member of
FAU College Collections
Contributors
Kim, Chul
Srivastava, Sapeckshita
Rice, Marian
Godenschwege, Tanja A.
Bentley, Brooke
Ravi, Saranya
Shao, Shuang
Woodard, Craig T.
Schwartz, Lawrence M.
Date Issued
2011-04-25
Note

Background: One of the hallmarks of Alzheimer’s disease, and several other degenerative disorders such as Inclusion Body Myositis, is the abnormal accumulation of amyloid precursor protein (APP) and its proteolytic amyloid peptides. To better understand the pathological consequences of inappropriate APP expression on developing tissues, we generated transgenic flies that express wild-type human APP in the skeletal muscles, andthen performed anatomical, electrophysiological, and behavioral analysis of the adults.

Language
English
Type
Text
Identifier
3327608
Additional Information
Background: One of the hallmarks of Alzheimer’s disease, and several other degenerative disorders such as Inclusion Body Myositis, is the abnormal accumulation of amyloid precursor protein (APP) and its proteolytic amyloid peptides. To better understand the pathological consequences of inappropriate APP expression on developing tissues, we generated transgenic flies that express wild-type human APP in the skeletal muscles, andthen performed anatomical, electrophysiological, and behavioral analysis of the adults.
Department of Biological Science Charles E. Schmidt College of Science
Date Backup
2011-04-25
Date Text
2011-04-25
DOI
10.1186/1472-6793-11-7
Date Issued (EDTF)
2011-04-25
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing11735", creator="creator:OCABEZAS", creation_date="2011-12-16 14:37:42", modified_by="super:FAUDIG", modification_date="2013-06-14 08:52:10"

IID
FADT3327608
Person Preferred Name

Kim, Chul

creator

Physical Description

text/pdf[10p.]
PURL
http://purl.flvc.org/fcla/dt/3327608
Title Plain
Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakenss
URL
http://purl.flvc.org/fcla/dt/3327608
Origin Information

2011-04-25
Title
Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakenss
Other Title Info

Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakenss