The primary purpose of this study was to examine the impact of acute highintensity
interval Exercise (HIIE) on plasma cfDNA and IL-6 responses in obese and
normal-weight subjects. Fifteen subjects (8 obese and 7 normal-weight) were recruited to
participate in an acute HIIE protocol. Our results demonstrated a significant elevation
across time in plasma cfDNA and IL-6 immediately following acute HIIE, with no
difference between obese and normal-weight subjects. Furthermore, cfDNA was not
correlated with IL-6 in response to acute HIIE in either group. These findings indicate
that the obese state does not further exacerbate the release of acute HIIE-induced
inflammatory mediators (cfDNA and IL-6), which suggests that HIIE training may serve
as a time-effective exercise strategy to improve obesity-associated inflammation.