Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2008
EDTF Date Created
2008
Description
Taurine, an endogenous ammo acid and neuromodulator, has been found to be
neuroprotective against numerous forms of neurotoxicity including glutamate-induced
excitotoxicity. Previously we have shown that taurine inhibits glutamate-induced
calcium influx through VGCCs and NMDA receptors. Although the neuroprotective
effects of taurine against excitotoxicity have been attributed to its intracellular Ca2+
regulatory functions, the complete mechanism underling taurine neuroprotection has
remained unclear. Using primary rat cortical neuronal cell cultures, we have determined
key cytosolic components to the mechanism of taurine neuroprotection. In this study we
have found that taurine inhibits excitotoxicity by suppressing glutamate-induced
elevations in [Ca2+]i, preventing calpain activation, and inhibiting reductions in Bel-
2:Bax ratios and consequently activation of the intrinsic pathway.
neuroprotective against numerous forms of neurotoxicity including glutamate-induced
excitotoxicity. Previously we have shown that taurine inhibits glutamate-induced
calcium influx through VGCCs and NMDA receptors. Although the neuroprotective
effects of taurine against excitotoxicity have been attributed to its intracellular Ca2+
regulatory functions, the complete mechanism underling taurine neuroprotection has
remained unclear. Using primary rat cortical neuronal cell cultures, we have determined
key cytosolic components to the mechanism of taurine neuroprotection. In this study we
have found that taurine inhibits excitotoxicity by suppressing glutamate-induced
elevations in [Ca2+]i, preventing calpain activation, and inhibiting reductions in Bel-
2:Bax ratios and consequently activation of the intrinsic pathway.
Language
Type
Form
Extent
44 p.
Subject (Topical)
Identifier
FA00000788
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2008.
Charles E. Schmidt College of Science
FAU Electronic Theses and Dissertations Collection
Date Backup
2008
Date Created Backup
2008
Date Text
2008
Date Created (EDTF)
2008
Date Issued (EDTF)
2008
Extension
FAU
IID
FA00000788
Organizations
Attributed name: Florida Atlantic University
Attributed name: Charles E. Schmidt College of Science
Attributed name: Department of Biological Sciences
Person Preferred Name
Leon, Rebecca
Graduate College
Physical Description
application/pdf
44 p.
Title Plain
Taurine inhibits glutamate-induced excitotoxicity through a calpain dependent pathway
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2008
2008
Florida Atlantic University
Boca Raton, FL
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, FL
Sub Location
Digital Library
Title
Taurine inhibits glutamate-induced excitotoxicity through a calpain dependent pathway
Other Title Info
Taurine inhibits glutamate-induced excitotoxicity through a calpain dependent pathway