Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity

Twenty-four metabolites derived from marine sponges were evaluated for their cytotoxicities against two human tumor cell lines, non-small cell lung carcinoma A549 and colon adenocarcinoma HT-29, and against one murine leukemia cell line, P-388, and evaluated for their ability to effect signal transduction in a newly developed cell adhesion assay using an EL-4 cell line.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50096a015. This article may be cited as: Longley, R. E., McConnell, O. J., Essich, E., & Harmody, D. (1993). Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity. Journal of Natural Products, 56(6), 915-920. doi:10.1021/np50096a015

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #959.